Kickoff Chronicles: NFL Week 1 Fantasy Playbook & Projections for Thrilling Matchups in the Heart of Las Vegas

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Fantasy Football Playbook: Week 1 Overview (USA, 2025)

Author: Mike Clay
Date: September 5, 2025, 07:01 AM ET
Profile: Mike Clay is a recognized senior writer for ESPN, contributing extensively to fantasy football analysis and NFL coverage. He has been honored in the FSWA Hall of Fame and provides key projections for the ESPN Fantasy Football platform.


Week 1 is here! The NFL season kicked off with the Dallas Cowboys facing the Philadelphia Eagles. This weekly guide presents essential score predictions, over/under betting lines, win probability insights, and straightforward fantasy advice optimized for both season-long leagues and daily fantasy sports (DFS).

Whether you’re deciding on sit/start dilemmas or last-minute waiver wire moves, this guide will assist you in making informed decisions. For the first time, the Shadow Report has been integrated into the play-by-play analysis below, allowing us to evaluate defensive strategies and WR/CB matchups with precision—ensuring the best projections and waiver suggestions each week.

Format Clarification:

All advice is focused on 12-team PPR leagues with standard setup (1 QB, 2 RB, 3 WR, 1 flex, 1 K, and 1 D/ST). Recommendations often highlight “shallow” versus “deep” leagues. Player charts feature anyone projected for at least 6.0 fantasy points this week, including all defensive/special teams players. “Matchup” evaluations are based on a proprietary metric reflecting opposing defensive performance against specific positions throughout the current season.

(Note: Projections and rankings may vary slightly based on factors like player upside and risk. Updates will be made throughout the weekend leading up to kickoff.)


Game Projections:

  • Buccaneers vs. Falcons: Projected Score: Buccaneers 27, Falcons 23
    Over/Under: 49.5 | Win Probability: Buccaneers 64%
    Lineup Locks: Baker Mayfield, Bijan Robinson, Drake London, Mike Evans, Emeka Egbuka

    A.J. Terrell Jr. is expected to shadow Mike Evans, who has shown remarkable production in past matchups despite difficult defenses.

  • Bengals vs. Browns: Projected Score: Bengals 27, Browns 20
    Over/Under: 47 | Win Probability: Bengals 73%
    Lineup Locks: Joe Burrow, Ja’Marr Chase, Tee Higgins, Jerry Jeudy

    Jerome Ford, likely to lead the Browns’ backfield, is a solid flex option against a Bengals defense that has shown vulnerability.

  • Colts vs. Dolphins: Projected Score: Colts 23, Dolphins 22
    Over/Under: 44.8 | Win Probability: Colts 55%
    Lineup Locks: Jonathan Taylor, Tyreek Hill, Jaylen Waddle

    Miami’s cornerback injuries open doors for Colts’ receivers to shine; consider adding Michael Pittman Jr. and Josh Downs.

  • Patriots vs. Raiders: Projected Score: Patriots 25, Raiders 19
    Over/Under: 44.2 | Win Probability: Patriots 69%
    Lineup Locks: Ashton Jeanty, Jakobi Meyers

    New England’s Stefon Diggs returns after injury, with a favorable matchup against a shaky Raiders secondary.

  • Cardinals vs. Saints: Projected Score: Cardinals 24, Saints 19
    Over/Under: 42.1 | Win Probability: Cardinals 68%
    Lineup Locks: Kyler Murray, Alvin Kamara

    Backup QB Spencer Rattler’s debut makes Saints’ pass-catchers risky plays against a robust Cardinals defense.

  • Steelers vs. Jets: Projected Score: Steelers 20, Jets 18
    Over/Under: 38 (Lowest) | Win Probability: Steelers 60%
    Lineup Locks: Breece Hall, DK Metcalf, Garrett Wilson

    With limited offensive potential, Hall remains a viable start despite tough matchup dynamics.

  • Commanders vs. Giants: Projected Score: Commanders 26, Giants 20
    Over/Under: 46.2 | Win Probability: Commanders 68%
    Lineup Locks: Jayden Daniels, Terry McLaurin

    Running back dynamics for both teams hint at a split workload, favoring receiving backs in this matchup.

  • Jaguars vs. Panthers: Projected Score: Jaguars 24, Panthers 21
    Over/Under: 45 | Win Probability: Jaguars 60%
    Lineup Locks: Chuba Hubbard, Brian Thomas Jr.

    Expect a competitive backfield scenario for Jacksonville, while the Panthers’ rookie wideout Matthew Golden could be a standout.

  • Broncos vs. Titans: Projected Score: Broncos 25, Titans 18
    Over/Under: 43 | Win Probability: Broncos 75%
    Lineup Locks: Bo Nix, Tony Pollard

    Defensive matchups may inhibit top targets but still project a competitive scoring environment.

  • Seahawks vs. 49ers: Projected Score: Seahawks 23, 49ers 22
    Over/Under: 44.8 | Win Probability: Seahawks 56%
    Lineup Locks: Christian McCaffrey, Kenneth Walker III.

    Injuries could lead to unexpected performances; both teams are looking to establish offensive rhythms early in the season.


Stay tuned as we track the season and provide ongoing updates and insights to help elevate your fantasy football game.


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